Temporal Discrimination: Mechanisms and Relevance to Adult-Onset Dystonia

Frontiers in Neurology, 8: 625, (2017)
Conte A, McGovern E, Narasiham S, Beck R, Killian O, O’Riordan S, Reilly RB , Hutchinson M

The premotor syndrome of cervical dystonia: Disordered processing of salient environmental stimuli

Movement Disorders. (2017) doi: 10.1002/mds.27229
Hutchinson M, McGovern E, Narasiham S, Beck R, Reilly RB, Walsh C, Malone K, Tijssen M, O’Riordan S

Practice does not make perfect: Temporal discrimination in musicians with and without dystonia

Movement Disorders. 32(12): 1791-1792. (2017) doi: 10.1002/mds.27185
Killian O, McGovern E, Beck R, Beiser I, Narasiham S, Quinlivan B, O’Riordan S, Simonyan K, Hutchinson M, Reilly RB

A comparison of stimulus presentation methods in temporal discrimination testing

Physiological Measurements 38(2) (2017): N57-N64.
McGovern E, Butler JS, Beiser I, Williams L, Quinlivan B, Narasiham S, Beck R, O’Riordan S, Reilly RB , Hutchinson M

Disrupted superior collicular activity may reveal cervical dystonia disease pathomechanisms

Scientific Reports 7(1): 16753, (2017)
McGovern E, Killian O, Narasiham S, Quinlivan B, Butler JS, Beck R, Beiser I, Williams L, Killeen RP, Farrell M, O’Riordan S, Reilly RB , Hutchinson M

Menstrual cycle and the temporal discrimination threshold

Physiological Measurements 38(2): N65-N72, (2017)
McGovern E, O’Connor E, Beiser I, Williams L, Butler JS, Quinlivan B, Narasiham S, Beck R, Reilly RB , O’Riordan S, Hutchinson M

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Journal of Visualised Experiments, (131), e56310, doi:10.3791/56310 (2018)
Beck R, McGovern E, Butler JS, Birsanu D, Quinlivan B, Beiser I, Narasiham S, O’Riordan S, Hutchinson M, Reilly RB

Prevalence and Correlates of Anxiety & Depression in Cervical Dystonia

Proceedings of 22nd International Congress of Parkinson’s Disease and Movement Disorders, Hong Kong, 2018.
Al Hussona M, Chindukwe I, Dover J, Beck R, Reilly RB, O’Riordan S, Hutchinson M.

Trust the Patient not the Doctor: Health-related Quality of Life in Cervical Dystonia.

Proceedings of 22nd International Congress of Parkinson’s Disease and Movement Disorders, Hong Kong, 2018.
Al Hussona M, Chindukwe I, Dover J, Beck R, Reilly RB, O’Riordan S, Hutchinson M.

Saccade Behaviour in Cervical Dystonia

Oral presentation, The International Society of Electrophysiology and Kinesiology, Dublin, 2018.
Beck, R., Kneafsey, S., Al Hussona, M., Narasimham, S., O’Riordan, S., Hutchinson, M., Reilly, R.B.

Temporal discrimination threshold in musician’s dystonia – an endophenotype?

Proceedings of 22nd International Congress of Parkinson’s Disease and Movement Disorders, Hong Kong, 2018.
Borngräber F, Paulus T, Junker J, Paßmann S, Reilly R, Hutchinson M, Klein C, Kühn AA, Altenmüller E, Bäumer T, Schmidt A.

Optimization of Region of Interest Analysis of the Superior Colliculus for Improved Activation Detection in Cervical Dystonia

Proceedings of 22nd International Congress of Parkinson’s Disease and Movement Disorders, Hong Kong, 2018.
Narasimham S, McGovern E, Killian O, Beck R, Farrell M, O’Riordan S, Hutchinson M, Reilly RB.

Investigating Ensemble Learning for Multi-Modal Data Fusion and Classification in Cervical Dystonia

Proceedings of the Organization of Human Brain Mapping, Signapore, 2018.
Narasimham S, Meulemans A, Beck R, O’Riordan S, Hutchinson M, Reilly RB.

Temporal discrimination threshold and blink reflex recovery cycle in cervical dystonia – two sides of the same coin?

German DGN-Kongress, 2018.
Paulus T, Junker J, Weissbach A, Löns S, Reilly R, Hutchinson M, Klein C, Bäumer T.

Epidemiological, clinical and genetic aspects of adult onset isolated focal dystonia in Ireland

European Journal of Neurology 2016, 0: 1–9 doi:10.1111/ene.13133
Williams L, McGovern E, Kimmicha O, Molloy A, Beiser I, Butler JS, Molloy F, Logan P, Healy DG, Lynch T, Walsh R, Cassidy L, Moriarty P, Moore H, McSwiney T, Walsh C, O’Riordan S, Hutchinson M

Application of virtual reality head mounted display for investigation of movement: a novel effect of orientation of attention

J. Neural Eng. 13 (2016) 056006 (11pp) doi:10.1088/1741-2560/13/5/056006
Quinlivan B, Butler JS, Beiser I, Williams L, McGovern E, O’Riordan S, Hutchinson M, Reilly RB

Exploring the unknown: Electrophysiological and behavioural measures of visuospatial learning.

Eur J Neurosci. 2016 Feb 3. doi: 10.1111/ejn.13195. [Epub ahead of print]
Quinlivan B, Butler JS, Ridwan AR, Beiser I, Williams L, McGovern E, O’Riordan S, Hutchinson M, Reilly RB

Age-Related Sexual Dimorphism in Temporal Discrimination and in Adult-Onset Dystonia Suggests GABAergic Mechanisms

Front Neurol. 2015 Dec 14;6:258. doi: 10.3389/fneur.2015.00258. eCollection 2015
Butler JS, Beiser I, Williams L, McGovern E, Molloy F, Lynch T, Healy DG, Moore H, Walsh R, Reilly RB, O’Riordan S, Walsh C, Hutchinson M

Young women do it better: sexual dimorphism in temporal discrimination

Front Neurol. 2015 Jul 9;6:160. doi: 10.3389/fneur.2015.00160.
Williams L, Butler JS, Molloy A, McGovern E, Beiser I, Kimmich O, Quinlivan B, O’Riordan S, Hutchinson M, Reilly RB

Non-parametric bootstrapping method for measuring the temporal discrimination threshold for movement disorders

J. Neural Eng. 12 (2015) 046026 (7pp). doi:10.1088/1741-2560/12/4/046026
Butler JS, Molloy A, Williams L, Kimmich O, Quinlivan B, O’Riordan S, Hutchinson M, Reilly RB

Sun exposure is an environmental factor for the development of blepharospasm

J Neurol Neurosurg Psychiatry. 2016 Apr;87(4):420-4. doi: 10.1136/jnnp-2014-310266. Epub 2015 Apr 22
Molloy A, Williams L, Kimmich O, Butler JS, Beiser I, McGovern E, O’Riordan S, Reilly RB, Walsh C, Hutchinson M

A headset method for measuring the visual temporal discrimination threshold in cervical dystonia

Tremor Other Hyperkinet Mov (N Y). 2014 Jul 18;4:249. doi: 10.7916/D8TD9VF6. eCollection 2014.
Molloy A, Kimmich O, Williams L, Quinlivan B, Dabacan A, Fanning A, Butler JS, O’Riordan S, Reilly RB, Hutchinson M

An evaluation of the role of environmental factors in the disease penetrance of cervical dystonia

J Neurol Neurosurg Psychiatry. 2015 Mar;86(3):331-5. doi: 10.1136/jnnp-2014-307699. Epub 2014 Jun 24.
Molloy A, Williams L, Kimmich O, Butler JS, Beiser I, McGovern E, O’Riordan S, Reilly RB, Walsh C, Hutchinson M

Cervical dystonia: A disorder of the midbrain network for covert attentional orienting

Front Neurol. 2014 Apr 28;5:54. doi: 10.3389/fneur.2014.00054. eCollection 2014. Review.
Hutchinson M, Isa T, Molloy A, Kimmich O, Williams L, Butler JS, Molloy F, Moore H, Healy DG, Lynch T, Walsh C, Reilly RB, Walsh R, O’Riordan S

Temporal discrimination, a cervical dystonia endophenotype: penetrance and functional correlates

Mov Disord. 2014 May;29(6):804-11. doi: 10.1002/mds.25822. Epub 2014 Jan 30.
Kimmich O, Molloy A, Whelan R, Williams L, Bradley D, Balsters J, Molloy F, Lynch T, Healy D, Walsh C, O’Riordan S, Reilly RB, Hutchinson M

The endophenotype and the phenotype: temporal discrimination and adult onset dystonia

Mov Disord. 2013 Nov;28(13):1766-74. doi: 10.1002/mds.25676. Epub 2013 Oct 9.
Hutchinson M, Kimmich O, Molloy A, Whelan R, Molloy F, Lynch T, Healy DG, Walsh C, Edwards MJ, Ozelius O, Reilly RB, O’Riordan S

Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination

Mov Disord. 2013 Nov;28(13):1874-7. doi: 10.1002/mds.25581. Epub 2013 Jul 12.
Sadnicka A, Kimmich O, Pisarek O, Ruge D, Galea J, Kassavetis P, Parees I, Saifee TA, Molloy A, Bradley D, O’Riordan S, Zrinzo L, Hariz M, Bhatia KP, Limousin P, Foltynie T, Rothwell JC, Hutchinson M, Edwards MJ

A novel CACNA1A mutation associated with adult-onset, paroxysmal head tremor

Mov Disord. 2013 Jun;28(6):842-3. doi: 10.1002/mds.25489. Epub 2013 May 21.
Molloy A, Kimmich O, Martindale J, Moore H, Hutchinson M, O’Riordan S

Temporal discrimination thresholds in adult-onset primary torsion dystonia: an analysis by task type and by dystonia phenotype

J Neurol. 2012 Jan;259(1):77-82. doi: 10.1007/s00415-011-6125-7. Epub 2011 Jun 8
Bradley D, Whelan R, Kimmich O, O’Riordan S, Mulrooney N, Brady P, Walsh R, Reilly RB, Hutchinson S, Molloy F, Hutchinson M

Sporadic adult onset primary torsion dystonia is a genetic disorder by the temporal discrimination test

Brain. 2011 Sep;134(Pt 9):2656-63. doi: 10.1093/brain/awr194. Epub 2011 Aug 11.
Kimmich O, Bradley D, Whelan R, Mulrooney N, Reilly RB, Hutchinson S, O’Riordan S, Hutchinson M

Familial Adolescent-Onset Scoliosis and Segmental Dystonia

ENJ 2010; 2:(2). August 2010
Bradley D, O’Riordan S, Hutchinson M

Striatal morphology correlates with sensory abnormalities in unaffected relatives of cervical dystonia patients

J Neurol. 2009 Aug;256(8):1307-13. doi: 10.1007/s00415-009-5119-1. Epub 2009 Apr 8
Walsh R, Whelan R, O’Dwyer JP, O’Riordan S, Hutchinson S, O’Laoide R, Malone K, Reilly RB, Hutchinson M

Cervical Dystonia Presenting as a Phenocopy in an Irish SCA2 Family

Mov Disord. 2009 Feb 15;24(3):466-7. doi: 10.1002/mds.22387
Walsh R, O’Dwyer JP, O’Riordan S, Bradley D, Moroney J, Hutchinson M

Sporadic adult onset dystonia: sensory abnormalities as an endophenotype in unaffected relatives

J Neurol Neurosurg Psychiatry 2007;78:980-983 doi:10.1136/jnnp.2006.105585
Walsh R, O’Dwyer JP, Sheikh IH, O’Riordan S, Lynch T, Hutchinson M

Paroxysmal torticollis and blepharospasm following bilateral cerebellar infarction.

J Neurol. 2006 Dec;253(12):1644-5.
O’Rourke K, O’Riordan S, Gallagher J, Hutchinson M

Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

Neurology. 2005 Sep 27;65(6):938-40.
O’Dwyer JP, O’Riordan S, Saunders-Pullman R, Bressman SB, Molloy F, Lynch T, Hutchinson M

Inherited myoclonus-dystonia and epilepsy: further evidence of an association?

Mov Disord. 2004 Dec;19(12):1456-9.
O’Riordan S, Ozelius LJ, de Carvalho Aguiar P, Hutchinson M, King M, Lynch T

Familial adolescent-onset scoliosis and later segmental dystonia in an Irish family.

J Neurol. 2004 Jul;251(7):845-8.
O’Riordan S, Lynch T, Hutchinson M

Age at onset as a factor in determining the phenotype of primary torsion dystonia

Neurology. 2004 Oct 26;63(8):1423-6.
O’Riordan S, Raymond D, Lynch T, Saunders-Pullman R, Bressman SB, Daly L, Hutchinson M

Cervical dystonia following peripheral trauma – a case-control study.

J Neurol. 2004 Feb;251(2):150-5
O’Riordan S, Hutchinson M

Primary torsion dystonia due to the Tor1A GAG deletion in an Irish family.

Ir J Med Sci. 2002 Jan-Mar;171(1):31-2.
O’Riordan S, Cockburn D, Barton D, Lynch T, Hutchinson M